Which statements are part of the Bergonie and Tribondeau law?

• A. 1 and 2
• B. 1 and 3
• C. 1, 3, and 4
• D. 2 and 3

Answer: (C)

Radiosensitivity varies with cell characteristics: cells that divide actively and are less differentiated are more sensitive to radiation, while mature, highly differentiated cells with limited future division are more resistant. The Bergonié–Tribondeau law ties sensitivity to three main factors: the cell’s reproductive activity (how actively it can divide), its degree of differentiation (how specialized it is), and the length of its future division potential (how many more divisions it can still undergo). Because the correct choice includes statements that reflect high mitotic activity, low differentiation, and long remaining division potential, it aligns with the law. Statements that would imply mature or highly differentiated cells are equally or more sensitive, or that differentiation doesn’t affect sensitivity, don’t fit this principle.